• 【学习时刻】人民大学王义桅:金砖合作的“自信”与“自觉” 2019-10-17
  • 全国党媒信息公共平台2018全国两会融合报道实践 2019-10-17
  • 左凌仁的专栏作者中国国家地理网 2019-10-13
  • 高考评卷0分或满分须100%复核 数学想得满分需过二十几道关 2019-10-03
  • 2018陕西高考数学试题分析:注重基础知识 突出思维能力 2019-08-28
  • 《事业单位公开招聘分类考试公共科目笔试考试大纲解读》出版 2019-08-17
  • [雷人]知道土地的价值由什么形成么?跟面积有啥关系? 2019-07-24
  • 菊姐都靠它变美少女了,你恐怕能年轻个10岁! 2019-06-25
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  • 希望不是拿混吃等死做文章 2019-06-23
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  • “双降”利好带动业绩增长 嘉泽新能收获靓丽成绩单 2019-06-19
  • 网络赌球水很深,球迷们千万不要碰! 赢了钱分分钟取不出来 2019-06-09
  • 保护知识产权让广州创新更给力 2019-06-09
  • 郑永年:争名逐利抢流量,中国的知识分子怎么了? 2019-06-08
  • Comparison of the SuperARMS and Droplet Digital PCR for Detecting EGFR Mutation in ctDNA From NSCLC Patients
    Wei-neng Feng, Wei-quan Gu, Ning Zhao, et al.

    Super-ARMS and ddPCR share the similar accuracy for EGFR mutation detection in plasma biopsy; both methods predicted well the efficacy of EGFR-TKIs by detecting plasma EGFR status.

    Translational Oncology (2018) 11, 542–545

    Detection of EGFR mutations in plasma circulating tumour DNA as a selection criterion for frst-line geftinib treatment in patients with advanced lung adenocarcinoma (BENEFIT): a phase 2, single-arm, multicentre clinical trial
    Zhijie Wang, Ying Cheng, Tongtong An, et al.

    Detection of EGFR mutations in ctDNA is an effective method to identify patients who might beneft from frst-line geftinib treatment. Further analyses of dynamic alterations of EGFR mutations and accompanying gene aberrances could predict resistance to geftinib.

    www.thelancet.com/respiratory Published online July 12, 2018 //dx.doi.org/10.1016/S2213-2600(18)30264-9

    Use of SuperARMS EGFR Mutation Detection Kit to Detect EGFR in Plasma Cell-free DNA of Patients With Lung Adenocarcinoma
    Shaohua Cui, Lin Ye, Huimin Wang, et al.

    SuperARMS is a promising plasma-based assay for EGFR mutations, including T790M. It might be useful in advanced-stage lung adenocarcinoma patients whose tissue biopsy samples are insufficient for a traditional diagnostic EGFR assay or for patients with a poor performance status.

    Clinical Lung Cancer, 2017. https://doi.org/10.1016/j.cllc.2017.12.009

    Comparison of the Amplification Refractory Mutation System, Super Amplification Refractory Mutation System, and Droplet Digital PCR for T790M Mutation Detection in Non-small Cell Lung Cancer after Failure of Tyrosine Kinase Inhibitor Treatment
    Lucheng Zhu, Shirong Zhang, Yanping Xun, et al.

    In conclusion, the results from this prospective study indicated the important clinical impact of T790 M detection using plasma samples for NSCLC patients who failed after EGFR-TKI therapy. Well concordance among three assays indicated the feasibility of plasma ctDNA detection. The ddPCR assay had a high sensitivity and might be superior to ARMS and SuperARMS assays.

    Pathol. Oncol. Res., 2017. DOI 10.1007/s12253-017-0286-3

    Clinical validation of a highly sensitive assay to detect EGFR mutations in plasma cell-free DNA from patients with advanced lung adenocarcinoma
    Yuping Li, Hanyan Xu, Shanshan Su, et al.

    ADx-SuperARMS EGFR assay is likely to be a highly sensitive and specific method to noninvasively detect plasma EGFR mutations of patients with advanced lung adenocarcinoma. The EGFR mutations detected by ADx-SuperARMS EGFR assay could predict the efficacy of the treatment with first generation of EGFR-TKIs. Hence, EGFR blood testing with ADxSuperARMS could address the unmet clinical needs.

    PLOS ONE, August 22, 2017. https://doi.org/10.1371/journal.pone.0183331.

    Feasibility of cytological specimens for ALK fusion detection in patients with advanced NSCLC using the method of RT-PCR
    Yan Wang, Yu Liu, Chao Zhao, et al.

    Histological tissues are preferred for anaplastic lymphoma kinase(ALK)  fusion detection in non-small cell lung cancer(NSCLC). The aim of this study was to evaluate the feasibility of cytological sample as an alternative specimen for ALK fusion  testing in patients with advanced NSCLC. 
     

    LUNG CANCER, DOI: //dx.doi.org/doi:10.1016/j.lungcan. 2016.01.014

  • 【学习时刻】人民大学王义桅:金砖合作的“自信”与“自觉” 2019-10-17
  • 全国党媒信息公共平台2018全国两会融合报道实践 2019-10-17
  • 左凌仁的专栏作者中国国家地理网 2019-10-13
  • 高考评卷0分或满分须100%复核 数学想得满分需过二十几道关 2019-10-03
  • 2018陕西高考数学试题分析:注重基础知识 突出思维能力 2019-08-28
  • 《事业单位公开招聘分类考试公共科目笔试考试大纲解读》出版 2019-08-17
  • [雷人]知道土地的价值由什么形成么?跟面积有啥关系? 2019-07-24
  • 菊姐都靠它变美少女了,你恐怕能年轻个10岁! 2019-06-25
  • 泸州老窖集团有限责任公司 2019-06-25
  • 希望不是拿混吃等死做文章 2019-06-23
  • 新时代 中华儿女共筑中国梦 2019-06-23
  • “双降”利好带动业绩增长 嘉泽新能收获靓丽成绩单 2019-06-19
  • 网络赌球水很深,球迷们千万不要碰! 赢了钱分分钟取不出来 2019-06-09
  • 保护知识产权让广州创新更给力 2019-06-09
  • 郑永年:争名逐利抢流量,中国的知识分子怎么了? 2019-06-08
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